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Samir Dou, Nathalie Villa-Vialaneix, Laurence Liaubet, Yvon Billon, Mario Giorgi, Hélène Gilbert, Jean-Luc Gourdine, Juliette Riquet, David Renaudeau
1HNMR-Based metabolomic profiling method to develop plasma biomarkers for sensitivity to chronic heat stress in growing pigs
www.plosone.org
www.plosone.org
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(females)Tj
3.1521 0 Td
(and)Tj
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(castrated)Tj
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(males.)Tj
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(weaned)Tj
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(4)Tj
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(age)Tj
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(\(week)Tj
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(4\))Tj
1.0204 0 Td
(\(26.9)Tj
/F12 1 Tf
2.1657 0 Td
[()]TJ
/F8 1 Tf
0.7823 0 Td
(1.7)Tj
1.3663 0 Td
(d\).)Tj
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(the)Tj
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(growing)Tj
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(period)Tj
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(\(between)Tj
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(weeks)Tj
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(10)Tj
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0.9977 0 Td
(23\),)Tj
1.6895 0 Td
(pigs)Tj
1.7858 0 Td
(of)Tj
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(a)Tj
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(batch)Tj
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(6)Tj
0.6803 0 Td
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0.9865 0 Td
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(animal)Tj
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(phenotyping)Tj
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(11\))Tj
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(equipped)Tj
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2.6872 0 Td
(drinkers)Tj
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1.7008 0 Td
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(access)Tj
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1.0034 0 Td
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1.1679 0 Td
(libitum)Tj
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(a)Tj
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(diet)Tj
1.7008 0 Td
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(pellets)Tj
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1.7008 0 Td
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2.1487 0 Td
(or)Tj
1.0771 0 Td
(exceed)Tj
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(the)Tj
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(nutritional)Tj
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(requirements)Tj
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(growing-finishing)Tj
7.2624 0 Td
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1.0091 0 Td
(the)Tj
1.44 0 Td
(standard)Tj
3.651 0 Td
(INRA)Tj
2.5681 0 Td
(recommendations.)Tj
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Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 489.9968 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Data)Tj
2.3102 0 Td
(recording)Tj
ET
Q
q
1 j
1 J
0 w
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BT
/F13 1 Tf
1 TL
-0.004 Tc
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4.9492 0 Td
(measurements.)Tj
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(\(BW\))Tj
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(week)Tj
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(11)Tj
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(\(BW11\))Tj
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(week)Tj
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1.1679 0 Td
(\(BW23\).)Tj
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1.7858 0 Td
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(11)Tj
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1.1848 0 Td
(the)Tj
1.4684 0 Td
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(duration)Tj
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(week)Tj
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(23,)Tj
1.4003 0 Td
(the)Tj
1.4683 0 Td
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5.5843 0 Td
(\(Agroscan,)Tj
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(E.C.M,)Tj
3.0217 0 Td
(Angoul)Tj
/F12 1 Tf
[()]TJ
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(me,)Tj
5.0797 0 Td
(France\))Tj
3.2882 0 Td
(at)Tj
0.9524 0 Td
(6)Tj
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(different)Tj
-32.9383 -1.2983 Td
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(measured)Tj
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(the)Tj
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1.4683 0 Td
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2.8176 0 Td
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1.5591 0 Td
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1.3663 0 Td
(\(P2)Tj
1.593 0 Td
(site\))Tj
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(and)Tj
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(last)Tj
1.559 0 Td
(lumbar)Tj
3.1238 0 Td
(vertebra)Tj
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(5)Tj
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1.4683 0 Td
(midline)Tj
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1.2756 0 Td
(each)Tj
2.0296 0 Td
(side)Tj
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(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(pig.)Tj
1.6951 0 Td
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1.7859 0 Td
(average)Tj
-32.6152 -1.3039 Td
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(fat)Tj
1.2415 0 Td
(thickness)Tj
3.9231 0 Td
(\(ABFT,)Tj
3.1918 0 Td
(mm\))Tj
2.1997 0 Td
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1.6951 0 Td
(the)Tj
1.474 0 Td
(average)Tj
3.2258 0 Td
(value)Tj
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(of)Tj
1.0148 0 Td
(these)Tj
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(6)Tj
0.6973 0 Td
(measurements.)Tj
6.2532 0 Td
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-31.555 -1.2983 Td
(daily)Tj
2.1486 0 Td
(feed)Tj
1.8822 0 Td
(intake)Tj
2.6872 0 Td
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1.7008 0 Td
(recorded)Tj
3.7927 0 Td
(using)Tj
2.3924 0 Td
(electronic)Tj
4.1499 0 Td
(feeders)Tj
3.0388 0 Td
(\(ACEMA)Tj
4.0535 0 Td
(128,)Tj
1.8765 0 Td
(ACEMO,)Tj
3.9968 0 Td
(Pontivy,)Tj
-31.7194 -1.2983 Td
(France\))Tj
3.2881 0 Td
(either)Tj
2.5285 0 Td
(only)Tj
1.9786 0 Td
(during)Tj
2.9253 0 Td
(test)Tj
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(weeks)Tj
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(1112,)Tj
2.8629 0 Td
(1516)Tj
2.6419 0 Td
(and)Tj
1.7291 0 Td
(1920)Tj
2.6419 0 Td
(\(defined)Tj
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1.0148 0 Td
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2.8346 0 Td
(1\))Tj
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1.389 0 Td
(half)Tj
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(of)Tj
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(the)Tj
1.4683 0 Td
(pigs)Tj
1.8311 0 Td
(or)Tj
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(only)Tj
1.9729 0 Td
(during)Tj
2.931 0 Td
(test)Tj
1.5987 0 Td
(weeks)Tj
2.6079 0 Td
(1314,)Tj
2.8686 0 Td
(1718)Tj
2.6362 0 Td
(and)Tj
1.7291 0 Td
(2123)Tj
2.6419 0 Td
(\(defined)Tj
3.566 0 Td
(as)Tj
1.0148 0 Td
(period)Tj
2.8346 0 Td
(2\))Tj
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(for)Tj
1.3833 0 Td
(the)Tj
1.4683 0 Td
(other)Tj
-34.6901 -1.2983 Td
(pigs.)Tj
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3.1408 0 Td
(the)Tj
1.4683 0 Td
(remaining)Tj
4.3653 0 Td
(test)Tj
1.5988 0 Td
(weeks,)Tj
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(pigs)Tj
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1.7121 0 Td
(free)Tj
1.7234 0 Td
(access)Tj
2.6476 0 Td
(to)Tj
1.0261 0 Td
(a)Tj
0.652 0 Td
(conventional)Tj
5.4255 0 Td
(feed)Tj
1.8821 0 Td
(dispenser.)Tj
-32.36 -1.2982 Td
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1.61 0 Td
(calculated)Tj
4.2009 0 Td
(the)Tj
1.474 0 Td
(average)Tj
3.2258 0 Td
(daily)Tj
2.1487 0 Td
(feed)Tj
1.8822 0 Td
(intake)Tj
2.6872 0 Td
(\(ADFI\))Tj
3.1861 0 Td
(over)Tj
1.9786 0 Td
(the)Tj
1.4683 0 Td
(whole)Tj
2.6079 0 Td
(trial)Tj
1.8368 0 Td
(based)Tj
2.4775 0 Td
(on)Tj
1.2756 0 Td
(these)Tj
2.2507 0 Td
(mea-)Tj
-34.3103 -1.2983 Td
(surements,)Tj
4.575 0 Td
(as)Tj
1.0148 0 Td
(proposed)Tj
3.9515 0 Td
(by)Tj
1.1792 0 Td
([)Tj
0.83 0.64 0.02 0 k
(15)Tj
0 g
(].)Tj
2.0749 0 Td
(Rectal)Tj
2.6646 0 Td
(temperature)Tj
5.125 0 Td
(\(RT\))Tj
2.1316 0 Td
(and)Tj
1.7292 0 Td
(skin)Tj
1.8878 0 Td
(temperature)Tj
5.1307 0 Td
(\(ST\))Tj
1.9842 0 Td
(were)Tj
2.1203 0 Td
(mea-)Tj
-35.5688 -1.3039 Td
(sured)Tj
2.432 0 Td
(at)Tj
0.9525 0 Td
(23)Tj
1.1678 0 Td
(weeks)Tj
2.6079 0 Td
(of)Tj
1.0148 0 Td
(age)Tj
1.542 0 Td
(on)Tj
1.2756 0 Td
(resting)Tj
2.9594 0 Td
(animals.)Tj
3.5546 0 Td
(RT)Tj
1.4513 0 Td
(was)Tj
1.7008 0 Td
(measured)Tj
4.1045 0 Td
(using)Tj
2.3925 0 Td
(a)Tj
0.6519 0 Td
(digital)Tj
2.7269 0 Td
(thermometer)Tj
-30.5345 -1.2983 Td
(\(Microlife)Tj
4.2462 0 Td
(Corp.,)Tj
2.7269 0 Td
(Paris,)Tj
2.4378 0 Td
(France\),)Tj
3.5149 0 Td
(and)Tj
1.7292 0 Td
(ST)Tj
1.3096 0 Td
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(measured)Tj
4.1102 0 Td
(on)Tj
1.2756 0 Td
(the)Tj
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(at)Tj
0.9525 0 Td
(the)Tj
1.474 0 Td
(P2)Tj
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(site)Tj
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(a)Tj
0.6576 0 Td
(skin)Tj
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(surface)Tj
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(thermocouple)Tj
5.811 0 Td
(probe)Tj
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(\(type)Tj
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1.1169 0 Td
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(88002K-IEC,)Tj
5.4198 0 Td
(Omega)Tj
3.1068 0 Td
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(Inc.,)Tj
1.9842 0 Td
(Stamford,)Tj
-33.1537 -1.3039 Td
(ST,)Tj
1.5306 0 Td
(USA\))Tj
2.4548 0 Td
(connected)Tj
4.3483 0 Td
(to)Tj
1.0205 0 Td
(a)Tj
0.6576 0 Td
(microprocessor-based)Tj
9.0538 0 Td
(handheld)Tj
3.9799 0 Td
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5.5048 0 Td
(\(model)Tj
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-31.6344 -1.2983 Td
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5.1193 0 Td
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/F13 1 Tf
-7.0298 -1.2983 Td
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(sample)Tj
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1.4741 0 Td
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2.1203 0 Td
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1.4683 0 Td
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2.2563 0 Td
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(a)Tj
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(9)Tj
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(heparin.)Tj
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(2)Tj
0.6916 0 Td
(min)Tj
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(centrifuged)Tj
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0.9524 0 Td
(2,500)Tj
2.3471 0 Td
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0.686 0 Td
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(20)Tj
1.1679 0 Td
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(separate)Tj
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(plasma.)Tj
3.2541 0 Td
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(stored)Tj
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(frozen)Tj
2.7666 0 Td
(\(-80C\))Tj
3.2598 0 Td
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Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 211.9748 152.4472 cm
BT
/F13 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(1H)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 221.5559 148.0251 cm
BT
/F13 1 Tf
1 TL
-0.004 Tc
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(Magnetic)Tj
4.0989 0 Td
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4.6488 0 Td
(\()Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 347.5842 152.4472 cm
BT
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